The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.
نویسندگان
چکیده
In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
منابع مشابه
The association of ICAM E469K with cardiovascular characteristics of acromegaly.
OBJECTIVE It has been shown that genetic factors have a role in the development of acromegaly. We aimed to investigate the association between intercellular adhesion molecule (ICAM)-1 E469K polymorphism and some cardiovascular clinical parameters of acromegalic patients. PATIENTS AND METHODS We included 41 patients with acromegaly and 65 healthy subjects with similar age and sex to the study....
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ورودعنوان ژورنال:
- Neurology
دوره 66 8 شماره
صفحات -
تاریخ انتشار 2006